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FIELD OF THE INVENTION. The present invention relates to an attenuated coronavirus comprising a variant replicase gene, which causes the virus to have reduced pathogenicity. The present invention also relates to the use of such a coronavirus in a vaccine to prevent and/or treat a disease. BACKGROUND TO THE INVENTION.

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U.S. Provisional Patent Application No. 61/709,303 filed Oct. 3, 2012, entitled Modified Nucleoside, Nucleotide and Nucleic Acid Compositions, U.S. Provisional Patent Application No. exogenous unmodified nucleic acid …US8983682B1 * 2012-12-28 2015-03-17 Google Inc. Unlocking mobile-device and/or unmanned aerial vehicle capability in an emergency situation. US9051043B1 * 2012-12-28 2015-06-09 Google Inc. Providing emergency medical services using unmanned aerial vehicles. USD741751S1 * 2014-12-11 2015-10-27 SenseFly Ltd. Drone.US8983682B1 * 2012-12-28 2015-03-17 Google Inc. Unlocking mobile-device and/or unmanned aerial vehicle capability in an emergency situation. US9051043B1 * 2012-12-28 2015-06-09 Google Inc. Providing emergency medical services using unmanned aerial vehicles. USD741751S1 * 2014-12-11 2015-10-27 SenseFly Ltd. Drone.A slide-stopacuated by the magazine-follower to arrest the breech-slide in the open position when the magazine is empty,'has beenheretofore described and shown in the United States Patent- No. 708794, granted to me September 9, 1902, but the construction of the slide-stop as an integral part of the handle of the pivot-pin securing "the barrel and the breech …The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides …

Apr 28, 2016 · As shown in FIG. 1, the craft 10 using an inertial mass reduction device comprises of an outer resonant cavity wall 100, an inner resonant cavity 200, and microwave emitters 300. The outer resonant cavity wall 100 and the inner resonant cavity wall 200 form a resonant cavity 150. The microwave emitters 300 create high frequency electromagnetic ... Abstract. A spacecraft having a triangular hull with vertical electrostatic line charges on each corner that produce a horizontal electric field parallel to the sides of the hull. This field, interacting with a plane wave emitted by antennas on the side of the hull, generates a force per volume combining both lift and propulsion.USD511342S1 2004-08-04 2005-11-08 High Tech Computer, Corp. Handheld electronic device. USD511347S1 2004-09-21 2005-11-08 Kabushiki Kaisha Toshiba Digital audio player. US20050255897A1 2004-04-29 2005-11-17 Samsung Electronics Co., Ltd. Double sliding-type portable communication apparatus.

38,268. 2022. 35,315. 1,173. 12,077. 13,699. 62,264. In 2022, China was granted more patents than every other country combined. While this suggests that the …

Мы хотели бы показать здесь описание, но сайт, который вы просматриваете, этого не позволяет.Мы хотели бы показать здесь описание, но сайт, который вы просматриваете, этого не позволяет.Search by application number, patent number, PCT number, publication number or international design registration number. Application # All fields. Application # Patent # PCT # Publication # Intl. Design Reg. # search. Receive updates from the USPTO. Enter your email to subscribe or update your preferences.Online patent tools. Locate online patent services and information. Patent Center. Single interface replacement for EFS-Web, Private PAIR and Public PAIR. Electronic Business Center; Check application status. Check patent application status with Patent Center. Fees and payment. Pay maintenance fees and learn more about filing …Aug 30, 2016 · Today, we're announcing the addition of 11 more countries to Google Patents with over 41 million new patent publications, bringing the total to over 87 million publications from 17 patent offices around the world. Starting today, you can now search for patents and applications from Japan, South Korea, the United Kingdom, Spain, France, Belgium ...

an assay is used to determine whether the patient has KRas G12D mutation using a sample (e.g., a biological sample or a biopsy sample (e.g., a paraffin-embedded biopsy sample) from a patient (e.g., a patient suspected of having a KRas G12D-associated cancer, a patient having one or more symptoms of a KRas G12D-associated cancer, and/or a …

The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell …

UNrrn TATES PATENT OFFICE. ALEXANDER GLEASON, OF BUFFALO, NEIV YORK, ASSIGNOR TO THE BUF FALO ELEOTROTYPE AND ENGRAVING COMPANY, OF SAME PLACE. TIME-CHART. SPECIFICATION forming part of Letters Patent No. 497,917, dated May 23, 1893. Application filed August 15, 1892.The principle of operation of the silent subliminal presentation system is as follows: An audio signal in the upper frequency region of the audio spectrum (for example, 14,500 Hz) is modulated with the desired information. The type of modulation may be any type suitable for subliminal applications; frequency modulation (FM), phase modulation ...Includes an Advanced Search and Prior Art Finder. Take greater control of your Google Patents search, utilising search boxes for specific keyword or numeric …Mar 28, 2024 · What is Google Patents. Google Patents is Google's own patent search tool. It draws on patents from more than 100 of the biggest patent offices from around the world, enabling you to search across more than 120 million documents. As such it rivals the EPO's Espacenet for coverage. Full-text patent documents are indexed from 20 of the biggest ... Consolidated Rules – The patent rules in effect as of March 29, 2024. Subsequent Publications (After July 31, 2022) – A listing of documents that made changes to USPTO patent examining policies and procedures after July 31, 2022, and are under consideration for inclusion in a future publication of the MPEP. This listing is current as of ...

Publication Publication Date Title. US174465A 1876-03-07 Improvement in telegraphy. Hogan 1913 The heterodyne receiving System, and notes on the recent arlington-salem tests. US388333A 1888-08-21 Telegraph-receiver. US382195A 1888-05-01 Chaeles selden. We would like to show you a description here but the site won’t allow us. 2. An electronic cigarette, comprising: a housing; a mouthpiece on the housing; an LED at a first end of the housing; an air inlet for providing air into the housing; a battery and a sensor electrically connected to an electronic circuit board within the housing, with the sensor in a stream passage in the housing; a further embodiment of the invention is a process for stabilizing ascorbic acid for storage, the process comprising combining 0.2% to 0.5% of a cinnamic acid derivative, such as p-coumaric acid, ferulic acid, caffeic acid, sinapinic acid, a derivative thereof, or a combination thereof; 10% to 60% of a solvent comprising a glycol ether and an alkanediol; and water; … Google Patents is a search engine from Google that indexes patents and patent applications from the United States Patent and Trademark Office, European Patent Office, and World Intellectual Property Organization. These documents include the entire collection of granted patents and published patent applications from each database. Patent: A patent is a government license that gives the holder exclusive rights to a process, design or new invention for a designated period of time. Applications for patents are usually handled ...

US2082748A 1937-06-01 Combined socket and slotted screw. US3108623A 1963-10-29 Tools for recessed head fasteners. US2046840A 1936-07-07 Screw driver. US2046839A 1936-07-07 Screw. US3237506A 1966-03-01 Recessed head fasteners. US2046343A 1936-07-07 Screw. US2066484A 1937-01-05 Screw. US1910182A 1933-05-23 Slotted socket …The patent file contains at least one drawing executed in color. Copies of this patent with a color drawing will be provided by the Office upon request and payment of the necessary fee. FIG. 1 is a front view of a graphical user interface for a display screen or portion thereof showing our new design; and,

a further embodiment of the invention is a process for stabilizing ascorbic acid for storage, the process comprising combining 0.2% to 0.5% of a cinnamic acid derivative, such as p-coumaric acid, ferulic acid, caffeic acid, sinapinic acid, a derivative thereof, or a combination thereof; 10% to 60% of a solvent comprising a glycol ether and an alkanediol; and water; …Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) 2016-03-01 Filing date 2016-03-01 Publication date 2016-12-29 ... J. S. (2015). Thermodynamic model of a nervous system US Patent No. 2015/0379898 A1; Goldberg, J. S. (2016). Method to optimize electrode placement for …Apr 25, 2011 · Online patent tools. Locate online patent services and information. Patent Center. Single interface replacement for EFS-Web, Private PAIR and Public PAIR. Electronic Business Center; Check application status. Check patent application status with Patent Center. Fees and payment. Pay maintenance fees and learn more about filing fees and other ... Мы хотели бы показать здесь описание, но сайт, который вы просматриваете, этого не позволяет.Patent Citations (84) Publication number Priority date Publication date Assignee Title. Family To Family Citations. 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations. 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies.This patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results. A method is provided for acquiring and transmitting biometric data (e.g., vital signs) of a user, where the data is analyzed to determine whether the user is suffering from a viral infection, such as COVID-19. The method includes using a pulse oximeter to acquire at least pulse and blood oxygen saturation percentage, which is transmitted ...

The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the …

This invention is a training system that enables a human being to acquire sufficient hyperspace energy in order to pull the body out of dimension so that the person can walk through solid objects such as wooden doors. A human being is a hyperspace energy being living in a physical container or body that is comprised of 67% water.

Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) 2009-12-04 Filing date 2010-12-06 Publication date 2011-12-22 2010-12-06 Application filed by UBER Inc, Uber Technologies Inc filed Critical UBER Inc 2010-12-06 Priority to US12/961,493 priority Critical patent/US20110313804A1/enThomas Claburn. Thu 18 Apr 2024 // 00:45 UTC. Hewlett Packard Enterprise has filed a lawsuit against Inspur Group, China's largest server maker, for allegedly … Example 3 of said patent discloses that 18 PPM of said crystal devices could totally suppress the AIDS virus (page 6, line 5). Subsequent to the filing of the aforementioned patent, further testing revealed complete 100% destruction of the AIDS virus in vitro at 20 PPM, and the fact that said devices were harmless when ingested and inhaled ... 1. Start with a simple keyword search. Go to patents.google.com and enter the keywords in the search bar. Example query: oral care. This will returns patents …U.S. Provisional Patent Application No. 61/709,303 filed Oct. 3, 2012, entitled Modified Nucleoside, Nucleotide and Nucleic Acid Compositions, U.S. Provisional Patent Application No. exogenous unmodified nucleic acid …Data provided by IFI CLAIMS Patent Services. A method for administration of ibuprofen to a subject in need of ibuprofen treatment is provided, in which an oral dosage form comprising a therapeutically effective amount of ibuprofen and a therapeutically effective amount of famotidine is administered three times per day.A messenger ribonucleic acid (mRNA) comprising an open reading frame (ORF) that encodes at least two domains of a SARS-CoV-2 Spike protein, and less than the full length spike protein. 2. The mRNA of claim 1, wherein one of the two domains is an N-terminal domain (NTD) of a SARS-CoV-2 Spike protein. 3. US20200054559A1. The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at ... Provided herein is a novel method of game play and game components that in one embodiment are in the form of trading cards (10, 12, 40, 42, 44, 48, 54, 60, 64). However, the game components may take other forms, such as a board game, or the game may be played in different media, such as electronic games, video games, computer games, and …The device of claim 1, further comprising a compressed gas source within the container and piped to release compressed gas within the mosquito breeding bin. US14/549,3052014-11-202014-11-20Toxic mosquito aerial release system ActiveUS8967029B1(en) Priority Applications (1) Application Number.

Abstract. An intelligent automated assistant system engages with the user in an integrated, conversational manner using natural language dialog, and invokes external services when appropriate to obtain information or perform various actions. The system can be implemented using any of a number of different platforms, such as the web, email ...A method is provided for identifying and displaying video data of a user, either alone or together (in synchronization) with other data, such as biometric data acquired during a time that the video data was captured/received. The method includes storing biometric data separately from the video data, allowing the biometric data to be search quickly to …Description. Claims (79) Hide Dependent. The invention relates to a wheelchair for example a wheelchair for an active user, a method of manufacturing a wheelchair and a wheel for a wheelchair. In further aspects the invention relates to a wheelchair, a footrest for a wheelchair, a wheelchair having a light, and a seat back for a wheelchair, a ...Instagram:https://instagram. riverbenderwhere can i watch id channel for freeturning stone loginmy view board US20200054559A1. The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally …Oral pharmaceutical solution comprising a pharmaceutically acceptable salt of lisdexamfetamine, and a pharmaceutically acceptable aqueous carrier comprising a buffer and a cosolvent selected from the group consisting of a glycol, a polyol, and a mixture thereof, wherein the pH of the solution is from 5.5 to 9.0. The oral pharmaceutical … leminonorway translation We would like to show you a description here but the site won’t allow us.A magnesium-counter ion composition provided herein may be useful for administration to a subject presenting magnesium deficiency, mild cognitive impairment, Alzheimer's disease, attention deficit hyperactivity disorder, ALS, Parkinson's disease, diabetes, migraine, anxiety disorder, mood disorder, and/or hypertension. san diego to portland Feb 27, 2024 · Google Patents is a free online search engine and database provided by Google that allows users to search and explore millions of patents from around the world. It provides access to a vast collection of patent documents, including granted patents, patent applications, and patent publications. Google Patents is useful in a wide range of ... This application claims the benefit of U.S. Provisional Patent Application Serial No. 61/975,601 , filed April 4, 2014, entitled "Systems and Methods for Injectable Devices," incorporated herein by reference in its entirety. GOVERNMENT FUNDING. This invention was made with government support under Grant No.